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ea0029p1230 | Obesity | ICEECE2012

Proteomic analysis identifies adiponectin as a key plasma protein associated to vitamin D deficiency in pediatric obesity

Walker G. , Prodam F. , Ricotti R. , Riccomagno S. , Moia S. , Roccio M. , Bellone S. , Genoni G. , Petri A. , Bona G.

Key circulating molecules that link the emerging role of vitamin-D to pediatric obesity and its co-morbidities remain unclear. To identify potentially involved regulators, this study analyzed plasma proteoma from obese children dichotomized by 25OH-vitamin D (25OHD) levels and upon vitamin-D3 therapy in 25OHD deficient subjects.A total of 42 obese children (M/F=18/24, bmi>95° centile) were selected and divided according to 25OHD levels into defi...

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ea0029p1578 | Thyroid (non-cancer) | ICEECE2012

A novel familial variation of the thyroid hormone receptor beta gene (I276N) associated with resistance to thyroid hormone

Moia S. , Monzani A. , Prodam F. , Petri A. , Genoni G. , Ricotti R. , Agarla V. , Bona G.

Introduction: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome, first identified in 1967 by Refetoff, characterized by reduced organ responsiveness to thyroid hormone. The most typical pattern being an elevated serum free T4 (fT4) concentration in association with non-suppressed TSH, usually accompanied by high serum levels of free T3 (fT3), with a considerable inter-individual variation and heterogeneous phenotype. The most frequent defect which causes R...

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Endocrine Abstracts

Proteomic analysis identifies adiponectin as a key plasma protein associated to vitamin D deficiency in pediatric obesity

A novel familial variation of the thyroid hormone receptor beta gene (I276N) associated with resistance to thyroid hormone

BiosciAbstracts